Nxp-2 antibody

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

MJ antibody; MORC3 antibody

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General informationThis section has been translated automatically.

The anti-NXP antibody (MJ antibody; MORC3 antibody) is an antibody whose target autoantigen is a nuclear matrix protein. It was first described in patients with juvenile dermatomyositis (25%). The autoantibody is also found less frequently (5%) in patients with dermatomyositis. It is associated with severe disease, muscle contractures and a higher incidence of calcinosis. Organ involvement is less frequent in patients. Patients with this antibody constellation respond well to therapy.

LiteratureThis section has been translated automatically.

  1. Volc-Place B (2015) Dermatomyositis update. Dermatologist 66:604-610

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer