Myxoedema diffuseE03.8
Synonym(s)
diffuse myxodermia in hypothyroidism; Myxodermia diffuse in hypothyroidism; Myxoedema real; True myxoedema
DefinitionThis section has been translated automatically.
Diffuse accumulation of acid mucopolysaccharides and fluid in the skin in hypothyroidism (see below for classification of mucinoses).
EtiopathogenesisThis section has been translated automatically.
Congenital (primary myxoedema) or acquired (secondary myxoedema) disturbance in the synthesis of thyroid hormones (e.g. inflammation, see also postoperative myxoedema)
Clinical featuresThis section has been translated automatically.
Pale, dry, bloated, edematous skin. No dents after finger pressure. Bloated face, dumpy speech in macroglossia. Yellowish-white skin colour, especially on palmae and plantae and in the nasolabial area. Hyperkeratotic skin in places, also follicular keratoses, general sebostasis.
LaboratoryThis section has been translated automatically.
Primary hypothyroidism: T3 and T4 decrease, TSH increase. Secondary hypothyroidism: T3, T4 and TSH decrease. Also carotenoids.
HistologyThis section has been translated automatically.
Accumulation of basic substances, especially in the upper corium around hair follicles and blood vessels, histochemical mucin detection.
TherapyThis section has been translated automatically.
Treatment by internists. Substitution therapy after endocrinological clarification of the genesis. With hormone substitution, the skin changes usually decrease as well.
Progression/forecastThis section has been translated automatically.
Back formation under substitution.