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Mepivacaine
Synonym(s)
DefinitionThis section has been translated automatically.
Mepivacaine is a local anaesthetic of the amide type (prototype is lidocaine) with the molecular formula: C15H22N2O. Mepivacaine is mainly used for infiltration and conduction anaesthesia.
Pharmacodynamics (Effect)This section has been translated automatically.
Mepivacaine, like all Na+ blockers, leads to a blockade of the voltage-dependent Na channels. The influx of sodium into the nerve fibre is inhibited, the formation of an action potential is prevented.
Mepivacaine hydrochloride is a racemate of the (R)-form and (S)-form. In the field of block anaesthesia it is often used for peripheral nerve blocks. Mepivacaine has a rapid onset of action due to good diffusion in tissue and a duration of action between 1.5 and 3 hours.
Standard concentrationThis section has been translated automatically.
0,5-4 % (maximum 3 mg/kg bw).
Undesirable effectsThis section has been translated automatically.
Depending on the plasma level, neurological and cardiac symptoms (e.g. cardiac arrhythmia) may occur (e.g. under local anaesthetics)
PreparationsThis section has been translated automatically.
Meaverin®, Scandicain®