Images (31)
Melanoma nodularC43.L
Synonym(s)
Melanoma nodular type; Nodular malignant melanoma; Nodular melanoma; Nodular melanomalignoma; Primary nodular melanoma
DefinitionThis section has been translated automatically.
Aggressive and vertically growing malignant melanoma with a rather bad prognosis (5-JÜR depending on tumor thickness at 60%). Occurs mainly in fair-skinned, intensely sun-exposed people, either on previously unmodified skin (more rarely), or on a pre-existing melanocytic nevus. Nodular melanoma is the second most common form of melanoma (20-30% of all melanomas).
ManifestationThis section has been translated automatically.
m>w; preferred for skin types I and II; age: >50 years
LocalizationThis section has been translated automatically.
torso, head, neck
Clinical featuresThis section has been translated automatically.
One distinguishes between two forms of growth:
- Vertical type: Small, black or blue-black, smooth, hemispherical knot.
- Vertical/horizontal type: Black, irregularly configured node with horizontal and vertical growth. The nodule shows a thinned, parchment-like, also exfoliatively scaly surface. Not uncommon are crust formations or central erosions or ulcerations (bleeding and weeping). At the edge of the nodule tongue-shaped, brown, black or red plaques are found.
Incident light microscopy: Diffuse pigmentation is dominant, the regular pigment network may still be present at the edge.
High-resolution sonography: echoless tumor zone. Suitable for non-invasive thickness determination of the tumor parenchyma.
HistologyThis section has been translated automatically.
Spindly, epithelioid and polymorphic melanoma cells in the epidermis and dermis, extending into the subcutaneous fatty tissue. Strong inflammatory stroma reaction.
TherapyThis section has been translated automatically.
Corresponding to the malignant melanoma.
Progression/forecastThis section has been translated automatically.
Unfavorable, early invasive growth.