Mbp

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

Major Basic Protein

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DefinitionThis section has been translated automatically.

Group of relatively small, arginine-rich proteins consisting of a single chain of polypeptides.

General informationThis section has been translated automatically.

  • Presumed formation from a precursor rich in glutamine and aspartic acid. In contrast to the effective MBP, the precursor is not toxic. Intracellular can be transported safely through the endoplasmic reticulum. Maturation to the effective MBP in the granules of mast cells.
  • MBP is toxic to helminths and is therefore involved in immune reactions against parasites (primary task). Toxicity is also directed against epithelia of the respiratory tract (nasal mucosa, bronchi). It also has the ability to stimulate mast cells to release histamine. MBP plays an essential role in allergic and non-allergic inflammatory processes. It also inactivates the anaphylaxis mediator SRS-A.

OccurrenceThis section has been translated automatically.

In granules of eosinophil granulocytes.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer