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Lymphoepithelioma-like carcinomaC44.4

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Carcinoma Lymphoepithelioma-like; lymphoepithelioma-like carcinoma of the skin

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HistoryThis section has been translated automatically.

Swanson SA, 1988

DefinitionThis section has been translated automatically.

Rare, largely undifferentiated variant of a spinocellular squamous cell carcinoma with a characteristic fine-tissue mixed cell (lymphoepithelial) structure.

EtiopathogenesisThis section has been translated automatically.

Extracutaneous lymphoepithelioma-like carcinoma is often associated with the Epstein-Barr virus. There is a relationship to type III nasopharyngeal carcinoma (old name = Schmincke tumor).

ManifestationThis section has been translated automatically.

Occurrence mainly in older people 50-80 years

LocalizationThis section has been translated automatically.

Preferably affected are light-exposed areas such as the head and neck.

Clinical featuresThis section has been translated automatically.

The clinical picture shows an unspectacular skin-colored to slightly reddened solid node of 0.5-1.0 cm in size. Lymph node metastases are rare. Metastases in the liver, lungs or skeleton are equally rare. Uncharacteristic coincidental finding.

HistologyThis section has been translated automatically.

Mostly well delimitable dermal tumor consisting of plump epithelial strands, in places with ductal structures (CEA-positive), of irregular, in places light-cell epithelial cells mixed in and surrounded by dense infiltrates of mature lymphocytes (T cells) and plasma cells.

Differential diagnosisThis section has been translated automatically.

Metastasis of nasopharyngeal lymphoepithelial carcinoma; cutaneous lymphoma; basal cell carcinoma. Merkel cell carcinoma

TherapyThis section has been translated automatically.

Excision with a safety distance of at least 1 cm with subsequent radiotherapy.

LiteratureThis section has been translated automatically.

  1. Ko T et al (1997) Lymphoepithelioma-like carcinoma of the skin. J Dermatol 24: 104-109
  2. Lind AC et al (1999) Lymphoepithelioma-like carcinoma of the skin with apparent origin in the epidermis--a pattern or an entity? A case report. Cancer 85: 884-890
  3. Oliveira CC et al (2018) Lymphoepithelioma-like carcinoma of the skin. To Bras Dermatol 93:256-258.
  4. Sagatys E et al (2003) Lymphoid lost and found. On J Dermatopathol 15: 159-161
  5. Shek TW et al (1996) Lymphoepithelioma-like carcinoma of the skin. At J Dermatopathol 18: 637-644
  6. Swanson SA et al (1988) Lymphoepithelioma-like carcinoma of the skin. Mod Catholic 1: 359-365

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer