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Loose anagen hair syndromeL73.8

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

loose anagen hair; Loose anagen hair; Loose anagen-hair of childhood; Loose anagen hair syndrome; Loose anagen syndromes; Noonan-like syndrome with loose anagen hair; Phenomenon of easily pullable hair

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HistoryThis section has been translated automatically.

Nödl, 1986

DefinitionThis section has been translated automatically.

Rare growth disorder of the scalp hairs occurring in children with greatly increased depilatability of the scalp hairs.

EtiopathogenesisThis section has been translated automatically.

Unsolved. In some families autosomal dominant inheritance with variable expression of a mutation of the K6HF gene is discussed, which leads to a disturbed attachment of hair shaft and root sheath.

ManifestationThis section has been translated automatically.

Small and schoolchild age.

Clinical featuresThis section has been translated automatically.

Already with a light pull the hairs can be depilated in tufts and painlessly. Often several, sometimes larger bald patches. Prompt regrowth of new hairs. The hair appears clinically inconspicuous.

Syndromal occurrence: The "loose anagen hair syndrome" can occur in the context of RASopathies, such as Noonan-like syndrome (Mazzanti syndrome), with cardiological defects, growth retardation, hyperpigmented skin.

HistologyThis section has been translated automatically.

The hair shaft cross-sections are irregularly oval or drop-shaped. Gap formation between inner and outer root sheath. Merging of the individual layers of the inner root sheath to form a homogeneous envelope and crumbly disintegration often already below the middle of the follicle.

DiagnosisThis section has been translated automatically.

In the trichogram almost exclusively thin anagen hairs without root sheaths.

TherapyThis section has been translated automatically.

No causal therapy known. Avoid traction. Wearing a hair net at night.

Progression/forecastThis section has been translated automatically.

Not exactly known, possibly it is a temporary maturation disorder with regression during puberty. This course distinguishes the clinical picture from the Short Anagen Hair Syndrome, which apparently shows no regression tendencies.

LiteratureThis section has been translated automatically.

  1. Gripp KW et al (20143) Expanding the SHOC2 mutation associated phenotype of Noonan syndrome with loose anagen hair: structural brain anomalies and myelofibrosis. Am J Med Genet A 161A: 2420-1430
  2. Mazzanti L et al (2003) Noonan-like syndrome with loose anagen hair: A new syndrome? On J Med Genet 118A: 279-286
  3. Tosti A et al (2002) Loose anagen hair syndrome and loose anagen hair. Arch Dermatol 138: 521-522
  4. Chapalain V et al (2002) Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study. Arch Dermatol 138: 501-506
  5. Mazzanti L et al (2003) Noonan-like syndrome with loose anagen hair: a new syndrome? On J Med Genet 118A: 279-286
  6. Nödl F, Zaun H, Zinn KH (1986) Increased epilatability of anagen hairs in children as a result of a maturation defect of the follicles with disturbed attachment of hair shaft and root sheath. The phenomenon of easily pullable hairs. Nude Dermatol 12: 55-57
  7. Fence H (1984) Differential diagnosis of alopecia in children. In: Happle R, Grosshans E (Eds). Pediatric dermatology. Springer, Berlin, pp. 157-166

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer