Lichen planus e medicationeL43.8

Lichen planus triggered or induced by medications. The following medications can trigger lichen planus:

• Gold salts
• Antimalarials
• Arsenic compounds
• Beta-blockers (non-ACE inhibitors)
• diuretics
• Antibiotics
• NSAIDS
• Phenothiazines
• Heavy metals
• Analgesics(naproxen -Güneş AT et al. 2006)
• Denosumab (antibody approved as an osteoporosis drug). Lichen planus occurs a median of 3-4weeks after application of the antibody (Boyd I 2016).
• TNF- alpha inhibitors ( McCarthy M et al. 2015).

Discontinue or transfer the triggering medication, otherwise according to the Lichen planus.

1. Boyd I (2016) Denosumab and lichen planus WHO Pharmaceutical Newsletter 6: 155.
2. Clayton R et al (2010) Mucosal and vulval) lichen planus in women: are angiotensin-converting enzyme inhibitors protective, and beta-blockers and non-steroidal anti-inflammatory drugs associated with the condition? Clin Exp Dermatol 35:384-387.
3. Gorouhi F et al (2014) Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. ScientificWorldJournal doi:10.1155/2014/742826.

4. Güneş AT et al (2006) Naproxen-induced lichen planus: report of 55 cases. Int J Dermatol 45:709-712.

5. McCarty M et al (2015) Lichenoid Reactions in Association with Tumor Necrosis Factor Alpha Inhibitors: A Review of the Literature and Addition of a Fourth Lichenoid Reaction. J Clin Aesthet Dermatol 8:45-49.
6. Zaraa I et al (2013) Lichen planus pemphigoides: four new cases and a review of the literature. Int J Dermatol 52:406-412.