Lenner's lymphomaC84.3
Synonym(s)
atypical lymphoepitheloid cell proliferation; epitheliodcellular lymphogranulomatosis; Lymphoepitheloid cell proliferation atypical; lymphoepitheloid lymphoma; Lymphoma lymphoepitheloides; Proliferation lymphoepitheloid cell
HistoryThis section has been translated automatically.
Lennert and Mestdagh, 1968
DefinitionThis section has been translated automatically.
Epithelial cell-rich, small cell peripheral cutaneous T-cell lymphoma, which is very close to lymphogranulomatosis. Occasionally, specific infiltrates of the skin were observed.
Clinical featuresThis section has been translated automatically.
- Skin lesions: truncated, mostly follicularly bound, small, skin-coloured to red, rough papules, which can conglomerate to larger plaques with a shiny surface. Scarring alopecia, ulcerations (especially genital).
- Extracutaneous manifestations: mediastinal, hiliary lymph node enlargement and intrapulmonary round foci.
HistologyThis section has been translated automatically.
In lymph nodes, bone marrow and affected skin, T-cell infiltrate rich in epithelial cells is present. Focally, histiocytes, epitheloid cells and UCHL1-positive lymphocytes are present.
TherapyThis section has been translated automatically.
Polychemotherapy (e.g. COPP and/or ABVD scheme), radiotherapy, excision of single foci.
LiteratureThis section has been translated automatically.
- Kim H, Jacobs C et al (1978) Malignant lymphoma with a high content of epitheloid histiocytes. Cancer 41: 620-635
- Kojima H et al (2003) Rapidly progressive Lennert's lymphoma terminating in fulminant hepatic failure. Leuk lymphoma 44: 1409-1412
- Lennert K, Mestdagh J (1968) Lymphogranulomatoses with constantly high epithelial cell content. Virchows Arch Path Anat 344: 1-20
- Roundtree JM, Burgdorf WHC et al (1980) Cutaneous involvement in Lennert's lymphoma. Arch. Dermatol. 116: 1291-1294
- Uppenkamp M et al (2002) Classification of malignant lymphoma. Oncology 25: 563-570