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Intravascular papillary endothelial hyperplasiaI99

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 03.08.2021

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Synonym(s)

Hemangioendotheliomas vegetante intravasculaire; intravascular papillary endothelial hyperplasia; Masson`s tumour; Pseudoangiosarcoma Masson

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HistoryThis section has been translated automatically.

Masson, 1923

DefinitionThis section has been translated automatically.

Reactive (benign) endothelial proliferation occurring during the organisation of a thrombosed vessel, primarily endovascular, less frequently extravascular (e.g. during the organisation of a haematoma), in stages. Extension to the perivasal connective tissue is possible in later stages. This proliferation mechanism may also occur in preexisting vascular tumors or malformations, e.g., hemangiomas, granuloma pyogenicum, or nevus flammeus.

LocalizationThis section has been translated automatically.

Mostly skin or subcutis of extremities (fingers), head, neck, or shoulder; also in oral mucosa (Vieira CC et al. 2021); rarely in genital area.

Clinical featuresThis section has been translated automatically.

A blue-red, deep dermal or subcutaneously located, firm, slowly enlarging nodule of varying size (Ø max. 4-5 cm), usually associated with a larger vessel, which is not necessarily clinically recognizable as a vascular lesion.

HistologyThis section has been translated automatically.

Mostly still recognizable, larger venous vessels with thrombotic material interspersed with endothelium-lined septa and papillae. Sponge-like aspect with bizarre, communicating cavities. No endothelial mitoses, no multilayering.

Differential diagnosisThis section has been translated automatically.

From the histological aspect all neoplasias with endothelial papillae, e.g. angiosarcoma, retiform hemangioenthelioma, endovascular papillary angioendothelioma.

LiteratureThis section has been translated automatically.

  1. Branton PA et al (2003) Papillary endothelial hyperplasia of the breast: the great impostor for angiosarcoma: a clinicopathologic review of 17 cases. Int J Surg Pathol 11: 83-87

  2. Han Yet al. (2019) Intravascular papillary endothelial hyperplasia occurring in the foot: A case report and review of literature. Medicine (Baltimore) 98:e16391.

  3. Mahapatra QS et al. (2015) Intravascular papillary endothelial hyperplasia: An unusual histopathological entity. Indian Dermatol Online J 6: 277-279.
  4. Masson P (1923) Hemangioendothelioma vegetant intravasculaire. Bull Soc Anat 93: 517-523
  5. Pegado PF et al (2015) Intravascular papillary endothelial hyperplasia (Masson tumor) mimicking a sarcoma and developing from an arteriovenous hemodialysis fistula. Skeletal Radiol 44:859-862.
  6. Renshaw AA, Rosai J (1993) Benign atypical vascular lesions of the lip. A study of 12 cases. Am J Surg Pathol 17: 557-565.
  7. Shah HC et al (2014) Intravascular papillary endothelial hyperplasia (Masson's tumor) of the scalp with intracranial extension. J Pediatr Neurosci 9: 260-262.

  8. Vieira CC et al. (2021) Intravascular papillary endothelial hyperplasia in the oral mucosa and jawbones: A collaborative study of 20 cases and a systematic review. J Oral Pathol Med 50:103-113.

  9. Yamamoto T et al (2000) Recurrent intravascular papillary endothelial hyperplasia of the toes. Dermatology 200: 72-74

Authors

Last updated on: 03.08.2021

Author: Prof. Dr. med. Peter Altmeyer