Interferon gamma

Authors:Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

Last updated on: 29.10.2020

Synonym(s)

gamma interferon; gamma-interferon; IFN gamma; IFN-gamma; IFN γ; IFN-γ; INF gamma; Interferon-gamma; Interferon-γ; γ Interferon

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DefinitionThis section has been translated automatically.

Cytokine.

Half-lifeThis section has been translated automatically.

5 h

Pharmacodynamics (Effect)This section has been translated automatically.

Induction of IL 2 production in T-helper cells. Expression of HLA class II antigens. Stimulation of monocytes and macrophages for TNF α production. Induction of the expression of IgG receptors on neutrophil granulocytes.

IndicationThis section has been translated automatically.

Therapeutic use with:

Chronic granulomatous diseases, leprosy, visceral leishmaniasis, infections with atypical mycobacteria in patients with CD 4-positive T cells deficiency.

Also in: rheumatoid arthritis, renal cell carcinoma, malignant melanoma, Schmincke tumors, CML, hairy cell leukemia, myelodysplastic syndrome, acute leukemia.

Limited indicationThis section has been translated automatically.

Pregnancy, nursing.

Dosage and method of useThis section has been translated automatically.

Pat. > 0,5 m2 KO: 3 times/week 50 μg s.c., Pat. < 0,5 m2 KO: 3 times/week 1,5 μg/kg KG.

Undesirable effectsThis section has been translated automatically.

Flu-like symptoms, dyshidrosis, dyspnoea, BB changes, transaminase increase, acute kidney failure, photosensitization, confusion, visual disturbances.

InteractionsThis section has been translated automatically.

Fluorouracil leads to a mutual enhancement of the effect.

ContraindicationThis section has been translated automatically.

Pregnancy, hypersensitivity to human serum albumin, autoimmune diseases, severe liver and kidney dysfunction.

PreparationsThis section has been translated automatically.

Imukin

Authors

Last updated on: 29.10.2020

Authors: Prof. Dr. med. Peter Altmeyer Prof. Dr. med. Martina Bacharach-Buhles