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Hyperplasia, focal epithelialB07
Synonym(s)
HistoryThis section has been translated automatically.
Heck, 1963; Archard, Heck and Stanley, 1965
DefinitionThis section has been translated automatically.
Rare, warty, mucosa-colored papulesand plaques of the oral mucosa caused by human papillomaviruses (V.a. HPV types 13 u. 32; rare detection of HPV types 1,6,11). The disease is clustered in members of the Inuit and Native American populations in South America. In children: comorbidity with HIV infection is known.
Occurrence/EpidemiologyThis section has been translated automatically.
Especially among Indians, South Americans and Asians. Less frequently in Europeans. Occasional familial clustering has also been described.
EtiopathogenesisThis section has been translated automatically.
In larger studies > 85% of patients were HPV positive. HPV32 was detected in 50%, HPV6 in 30% and HPV40 in 5%. HPV32 but not HPV6 was detected in HIV infected patients.
ManifestationThis section has been translated automatically.
LocalizationThis section has been translated automatically.
Oral mucosa; mainly lip red (here on the mucosal side of the lower lip); corner of the mouth; cheek mucosa (about 65 % of patients); more rarely the floor of the mouth or the palate is affected.
Clinical featuresThis section has been translated automatically.
Multiple wart-like, oral mucosa-coloured to whitish, persistent over months and years, broadly seated on the base, soft papules with a tendency to confluence. Size: 0,5-1,0 cm. Aggregation of the growths may result in larger, humpy beds.
HistologyThis section has been translated automatically.
Acanthosis with large ballooned cells in the stratum spinosum, papillomatosis. The retellions are extended and partly anastomosed. Mitosis figures in the stratum basale.
TherapyThis section has been translated automatically.
If necessary, excision or cauterization with subsequent curettage. Spontaneous healing possible. Successful local therapy with solutions containing vit. A-acid has been reported. A high spontaneous remission is guaranteed!
LiteratureThis section has been translated automatically.
- Archard HO, Heck JW, Stanley HR (1965) Focal epithelial hyperplasia: an unusual and mucosal lesion found in Indian children. Oral Surg Oral Med Oral Catholic 20: 201-212
- Feller L et al (2010) Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. SADJ 65:172-175Gökahmetoğlu
S et al(2015)Focal epithelial hyperplasia in a Turkish family. Infez Med 22:322-325 - Khanal S et al (2016) Human papillomavirus detection in histologic samples of multifocal epithelial hyperplasia
: a novel demographic presentation.
Oral Surg Oral Med Oral Pathol 120:733-743. - Kose O et al (2001) Focal epithelial hyperplasia treated with interferon alpha-2a. J Dermatologist Treat 12: 111-113
- Knoth W et al (1978) Hyperplasia multilocularis mucosae oris HECK (Sog. Focal epithelial hyperplasia). Z Hautkr 53: 675-679
- Nartey NO et al (2002) Focal epithelial hyperplasia: report of six cases from Ghana, West Africa. J Clin Pediatr Dent 27: 63-66
- Sabeena S et al (2016) Papilloma of lip associated with human papilloma viruses-32 infection in a child. Indian J Med Microbiol 34:97-99
- Syrjanen S (2003) Human papillomavirus infections and oral tumors. Med Microbiol Immunol (Berl) 192: 123-128
- Witkop CJ Jr, Niswander JD (1965) Focal epithelial hyperplasia in Central and South American Indians and Latinos. Oral Surg Oral Med Oral Catholic 20: 213-217