Atopy sign: Rarefication of the lateral eyebrows in atopic eczema.
Also called"Queen Anne sign". Eugène Hertoghe was an endocrinologist from Belgium (Antwerp). He himself never published the Hertoghe sign.
In the literature, this phenomenon is also called the Queen Anne sign because the Queen of Denmark is depicted in a 1612 portrait with rarefied lateral eyebrows as she mourns the death of her son Henry.