Gross cystic disease fluid protein-15
Synonym(s)
GCDFP-15 "Gross Cystic Disease Fluid Protein 15; PIP; prolactin-induced protein; SABP
DefinitionThis section has been translated automatically.
Gross cystic disease fluid protein 15 (GCDFP-15), also known as "prolactin-induced protein" or PIP, is a protein produced by salivary sweat and tear glands. PIP binds to aquaporin-5 in salivary and lacrimal glands. This process leads to the transport of aquaporin-5 into the apical membrane. PIP has binding sites for actin. The production of PIP is stimulated by prolactin and androgens in the salivary, lacrimal and sweat glands and slowed down by estrogens.
In histological diagnostics, antibodies directed against GCDFP-15 are used as immunohistochemical diagnostic markers for apocrine and eccrine sweat glands, accessory salivary glands and mammary glands.
LiteratureThis section has been translated automatically.
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