Antimycotic. out of trade in Germany!
Griseofulvin
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
22 h
Pharmacodynamics (Effect)This section has been translated automatically.
Fungistatic effect, inhibition of mitosis of dermatophytes. Incorporation into newly formed keratin of hair roots, nail matrix and epidermis (latency period 30 days).
IndicationThis section has been translated automatically.
Systemic in severe dermatophyte infections. Approved antimycotic against trichophyton and microsporum species in children. Topically used for the treatment of superficial dermatomycoses and for supportive therapy of Tinea unguium.
Dosage and method of useThis section has been translated automatically.
- Cream: Apply 1-3 times/day to the affected skin areas.
- Systemic: 0.5-1 g/day for 3 months p.o., children < 14 years: 10-20 mg/kg bw/day (equivalent to 1-3.5 tablets of a preparation containing 125 mg griseofulvin); treatment duration: 4-8 weeks. Take unchewed with a fatty meal with liquid.
Standard concentrationThis section has been translated automatically.
5% as cream.
Undesirable effectsThis section has been translated automatically.
- Topical: Paragroup allergy.
- Systemic: nervousness, gastrointestinal problems, headache, fatigue, xerostomia, blood count changes (leukopenia, neutropenia, monocytosis).
Notice! Under griseofulvin, check the blood count twice in the first month of treatment, later every 2-3 months. Due to potential teratogenicity, effective contraception should be used, whereby the effect of oral contraceptives is reduced. Men should not conceive children during treatment and up to 6 months afterwards! Hepatotoxicity!
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
Liver and kidney damage (e.g. acute hepatic porphyria), pregnancy, lactation, collagenosis, acute hepatic porphyria.
Notice! Caution in case of known penicillin allergy (griseofulvin is produced by Penicillium species).
PreparationsThis section has been translated automatically.
Likuden, Gricin cream, Griseo 125
LiteratureThis section has been translated automatically.
- Seebacher C et al (2006) Tinea capitis. J Dtsch Dermatol Ges 4: 1085-1091
TablesThis section has been translated automatically.
Significant interactions of griseofulvin
Anticoagulants, oral |
Griseofulvin degradation ↑, anticoagulant effect ↓ |
Barbiturates |
Griseofulvin-Wirkung↓ |
Contraceptives, oral |
Contraception ↓ |
Phenytoin |
Griseofulvin effect ↑ |