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Grinspan syndromeL43.8

Last updated on: 09.03.2026

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KeywordsThis section has been translated automatically.

Diabetes mellitus; hypertension; oral lichen planus;

DefinitionThis section has been translated automatically.

Grinspan syndrome (GS) is characterized by an association of diabetes mellitus, hypertension and oral lichen planus (Lamey PJ et al.1990).

EtiopathogenesisThis section has been translated automatically.

It is still unclear whether this is an independent disease or a lichenoid reaction as a result of taking medication to treat high blood pressure and diabetes.

Note(s)This section has been translated automatically.

A rare association of Grinspan syndrome with pemphigus vulgaris is noteworthy. In one case, this clinical constellation was triggered by a COVID-19 vaccination. (Saddik A et al. 2025).

LiteratureThis section has been translated automatically.

  1. Kökten N et al. (2018) Grinspan's Syndrome: A Rare Case with Malignant Transformation. Case Rep Otolaryngol 2018:9427650
  2. Lamey PJ et al.(1990) Grinspan's syndrome: a drug-induced phenomenon? Oral Surg Oral Med Oral Pathol 70:184-185
  3. Saddik A et al. (2025) Grinspan Syndrome Associated With Pemphigus Vulgaris Induced by COVID-19 Vaccination. Cureus 17:e88255.

Last updated on: 09.03.2026