Images (9)

Gigantean condylomaA63.0

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

Buschke-Loewenstein tumor; Buschke's Lion's Arch tumor; carcinoma-like condyloma; carcinoma verrucosum; Carcinoma verrucous of the genital region; Condyloma acuminatum giganteum; genital cancer; Giant condylomas; Giant Condylomata Acuminata of Buschke and Loewenstein; giant malignant condyloma

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

HistoryThis section has been translated automatically.

Buschke and Löwenstein, 1925

DefinitionThis section has been translated automatically.

Infiltrating giant form of the condyloma acuminata with perforation in the urethra or fenestration of the prepuce.

Some authors consider condylomata gigantea to be a group of verrucous carcinomas (see carcinoma verrucous).

Occurrence/EpidemiologyThis section has been translated automatically.

m:w=2.4:1

EtiopathogenesisThis section has been translated automatically.

Long-term (usually >10 years) persistent HPV infection (see below papilloma viruses , human) with transition to a verrucous carcinoma. Detection of papillomaviruses, especially the low-risk types HPV 6, HPV 11, HPV 56. 1x coinfection with the highly malignant alpha-mucosotropic HPV type 52 could be described (see below papillomaviruses, human). Coinfection with HIV is often detectable (up to 14% of patients - cited by Sporkert M 2017).

ManifestationThis section has been translated automatically.

Mainly occurring in male adults. Age of first manifestation: 20-40 years (median age at first diagnosis = 46.5 years - Sporkert M et al. 2017)).

Clinical featuresThis section has been translated automatically.

Tumour-shaped or cauliflower-like, exophytic and locally infiltrating giant condylomas in the genital and anal area. Aggressive growth with destruction of deeper lying tissue.

HistologyThis section has been translated automatically.

S.u. Carcinoma verrucous.

Differential diagnosisThis section has been translated automatically.

Differentiation from non-viral pigmented papillomas.

TherapyThis section has been translated automatically.

Organ-preserving surgical removal in healthy people. In very extensive cases and in case of localisation in the penis area, a penis amputation may be necessary.

Notice! Condylomata gigantea should always be histologically controlled! Focal invasion and recurrences are seen after surgery in up to 50% of cases! However, metastases are very rare!

Alternative: In special cases (e.g. inoperability at high age) a combination therapy with 5% Imiquimod ointment and CO 2 laser can be chosen: period 6 weeks; 3 times/week Imiquimod for 12 hours, then wash off, then laser ablation withCO2 laser and again therapy with Imiquimod for another 6 weeks.

Alternative: In individual cases a very good response to neoadjuvant or monotherapeutic radiochemotherapy (54Gy, Mitomycin-5-FU or Cispatin+5-FU) was reported.

AftercareThis section has been translated automatically.

Close-mesh surveillance.

LiteratureThis section has been translated automatically.

  1. Buschke A, Loewenstein L (1931) About carcinoma-like condylomata acuminata of the penis. Arch Dermatol Syphilol (Berlin) 163: 30-461
  2. Buschke A, Loewenstein L (1925) About carcinoma-like condylomata acuminata of the penis. Berl Klin Wschr 4: 1726-1728
  3. Gholam P et al (2009) Successful surgical management of giant condyloma acuminatum (Buschke-Löwenstein
    tumor) in the genitoanal region: a case report and evaluation of current therapies. Dermatology. 218:56-59.
  4. Grassegger A et al (1994) Buschke-Loewenstein tumor infiltrating pelvic organs. Br J Dermatol 130: 221-225
  5. Gross G, Gissmann L (1986) Urogenital and anal papillomavirus infections. Dermatologist 37: 587-596
  6. Heinzerling LM (2003) Treatment of verrucous carcinoma with imiquimod and CO2 laser ablation. Dermatology 207: 119-122
  7. Ishibuchi T et al (2014) Detection of human papillomavirus type 56in
    giant condyloma acuminatum. Acta Derm Venereol 94:482-483
  8. Qian G et al (2013) Giant condyloma acuminata of Buschke-Lowenstein: successfultreatment
    mainly by an innovative surgical method. Dermatol Ther 26:411-414
  9. Schwartz RA (1990) Buschke-Loewenstein tumor: Verrucous carcinoma of the penis. J Am Acad Dermatol 23: 723-727
  10. Seixas ALC et al (1994) Verrucous carcinoma of the penis - retrospective analysis of 32 cases. J Urol 152: 1476-1478
  11. Sporkert M et al (2017) Buschke-Löwenstein tumor. Dermatologist 68: 199-203

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer

Editor: Christoph Müller