Gestagens

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 07.10.2021

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DefinitionThis section has been translated automatically.

Female sex hormones that serve to create and maintain a pregnancy.

Pharmacodynamics (Effect)This section has been translated automatically.

Inhibition of estrogen-induced endometrial proliferation, cycle regulation in dysfunctional bleeding and cycle abnormalities.

IndicationThis section has been translated automatically.

Moderate forms of acne vulgaris, hirsutism, female alopecia androgenetica, oral contraception (see Table 1).

Limited indicationThis section has been translated automatically.

Z.n. apoplexy, Z.n. deep vein thrombosis, bladder mole, Z.n. intracerebral hemorrhage, endogenous depression, diabetes mellitus, epilepsy, Z.n. extrauterine pregnancy, Z.n. pemphigoid gestationis, heart failure, hypercholesterolemia, migraine, Z.n. myocardial infarction, renal failure, porphyria, Z.n. thromboembolism, thrombophlebitis.

Undesirable effectsThis section has been translated automatically.

Weight gain, menstrual disorders, mastopathy, virilization, gastrointestinal disorders, cholestasis, icterus, acne, chloasma, alopecia, allergic reactions, thrombosis, blood pressure rise, depression, headaches, visual disturbances, hearing loss, myalgias, arthralgias.

InteractionsThis section has been translated automatically.

See Table 2.

ContraindicationThis section has been translated automatically.

Pregnancy (virilization of female fetuses), lactation, restrained miscarriage, unclear vaginal bleeding, severe acute or chronic pregnancy. liver disease.

TablesThis section has been translated automatically.

Brief overview of common progestogens

Active substance

Concentration [mg]

Application

Examples of ready-to-use preparations

Chlormadinone acetate

2

p.o.

Gestafortin Tbl.

Dydrogesterone

10

p.o.

Duphaston tbl.

Hydroxyprogesterone caproate

250

i.m.

Proluton Depot Amp.

Levonorgestrel

0,03

p.o.

Microlut

0,052

p.o.

Mirena

Lynestrenol

5

p.o.

Orgametril tbl.

Medrogeston

5

p.o.

Prothil 5 mg tbl.

Medroxyprogesterone acetate

2,5/5/10

p.o.

Clinofem 2.5/5/10 tbl.

150

i.m.

Clinovir depot

Norethisterone acetate

1/5

p.o.

Norethisterone 1/5 mg

5

p.o.

Primolut Nor 5 tbl.

10

p.o.

Primolut Nor 10 tbl.

Norethisterone antate

200

i.m.

Noristerate

Progesterone

90

Gel

Crinone 8% vaginal gel

100

p.o.

Utrogest Kps.

10

Gel

Progestogel Gel

Major interactions of progestogens

Amoxicillin

Progestogen levels temporarily ↓ due to damage to intestinal flora

Ampicillin

Progestogen levels transient ↓ due to damage to intestinal flora

Barbiturates

Progestin degradation ↑, effect of low-dose progestins ↓

Butazones

Progestogen effect ↓

Carbamazepine

Effect of low-dose progestogens ↓

Insulin

Glucose tolerance disorder

Metformin

Glucose tolerance disorder

Phenytoin

Progestin degradation ↑

Rifampicin

Progestin depletion ↑

Sulfonylureas

Blood sugar lowering or ↓

Tetracyclines

Progestogen effect ↓ through damage to the intestinal flora

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Last updated on: 07.10.2021