Flucloxacillin

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

CAS number: 5250-39-5

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DefinitionThis section has been translated automatically.

Penicillinase-resistant betalactam antibiotic specially developed for the treatment of betalactamase-forming staphylococci. Flucloxacillin is therefore also referred to as "staphylococcal penicillin".

Flucloxacillin belongs to the group of isoxazolyl antibiotics, which also includes cloxacillin, dicloxacillin and oxacillin.

Half-lifeThis section has been translated automatically.

0,7–1 h

Spectrum of actionThis section has been translated automatically.

Infections with beta-lactamase-forming staphylococci (e.g. Staphylococcus aureus and Staphylococcus epidermidis), but also Streptococcus pyogenes, Klebsiella pneumoniae, Neisseria species, Bacillus anthracis (anthrax), Bacillus subtilis, Clostridia and Listeria monocytogenes are indicated.

Most enterococci are resistant to flucloxacillin.

IndicationThis section has been translated automatically.

Infections with flucloxacillin-sensitive germs (especially penicillinase-forming staphylococci) in infections of the skin, mucous membranes and soft tissue ( boils, abscesses, pyoderma, panaritium, paronychia, mastitis), infections of the respiratory tract, infections of the bones and bone marrow

Flucloxacillin also causes "non-antibiotic" immunological effects. For example, it has been successful in individual cases of dermatitis herpetiformis.

Pregnancy/nursing periodThis section has been translated automatically.

Strict indication (active ingredient is placental and passes into breast milk).

Dosage and method of useThis section has been translated automatically.

  • Adults: 3-4 times/day 1-2 g p.o., i.v. or i.m.
  • Children 10-14 years: 3-4 times/day 0,5 g.
  • Children 6-10 years: 3 times/day 0,25-0,4 g.
  • Children < 6 years: 40-50 mg/kg bw/day divided into 3 doses, max. 100 mg/kg bw/day.

Undesirable effectsThis section has been translated automatically.

Occasionally erythema nodosum, pruritus, urticaria, among others.

Rare gastrointestinal side effects (nausea, vomiting), hypernatremia, hypermagnesemia.

Furthermore, in rare cases flucloxacillin induces immune thrombocytopenia.

ContraindicationThis section has been translated automatically.

Penicillin allergy, liver dysfunction/ecterus under flucloxacillin therapy.

PreparationsThis section has been translated automatically.

Staphylex®

LiteratureThis section has been translated automatically.

  1. Jatzlauk G et al (2016) Flucloxacillin-induced immune thrombocytopenia. Transfusion 56:67-72.


Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer