Estrogen-progestin combinations

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Hormone preparations of female sex hormones. Classification see table 2.

IndicationThis section has been translated automatically.

Hormonal contraception, severe acne, seborrhea, alopecia androgenetica (see Alopecia androgenetica in women, Alopecia androgenetica in men), hirsutism in women, see Table 1.

Limited indicationThis section has been translated automatically.

Breastfeeding, 6 weeks before planned operations, smokers > 30 years, liver diseases, gallbladder diseases, kidney failure, heart failure, lipid metabolism disorders.

Undesirable effectsThis section has been translated automatically.

visual disturbances, weight gain, menstrual disorders, hirsutism, thrombosis, gastrointestinal disorders, liver tumors, cholestasis, jaundice, allergic reactions, chloasma, acne, rec. vulvovaginal candidiasis, blood pressure rise, dizziness, headache, epilepsy, depression, hearing disorders, see Table 3.

InteractionsThis section has been translated automatically.

See Table 4.

ContraindicationThis section has been translated automatically.

Pregnancy, acute and progressive liver diseases, intrahepatic cholestasis, liver tumors, hormone-dependent malignant tumors, Z.n. thrombosis, tendency to thrombosis, sickle cell anemia, difficult to adjust hypertriglyceridemia, otosclerosis, severe diabetes mellitus, unexplained uterine bleeding, difficult to adjust hypertension, migraine.

TablesThis section has been translated automatically.

Medical indications for estrogen-progestin combinations

Symptomatology

Type of preparation

Dysfunctional bleeding

progesterone

Hypermenorrhoea

progesterone

Dysmenorrhoea

low-dose

Ovarian functional cysts

monophasic

Premenstrual Syndrome

low-dose

Mastopathy I

progesterone

Endometriosis

progesterone

Hirsutism

antiandrogen


Overview of the most common estrogen-progestin combinations

Oestrogen

Single dose

[μg]

Gestagen

Single dose

[mg]

Finished preparations

Single-phase preparations

Ethinylestradiol

30

Norethisterone acetate

0,5

Conceplan M

30

Levonorgestrel

0,15

Microgynon

30

Levonorgestrel

0,05

NovaStep

30

Levonorgestrel

0,125

Minisiston

50

Lynestrenol

0,125

Gravistat

50

Lynestrenol

0,25

Neogynon

37,5

Lynestrenol

0,75

Ovoresta

30

Desogestrel

0,15

Marvelon

30

Gestodene

0,075

Femovan

30

Norethisterone

0,5

Conceplan M

20

Norethisterone

0,5

Eve 20

30

Chloromadinone acetate

2

Belara

Mestranol

50

Chloromadinone acetate

2

Gestamestrol N

Two-Phase Preparations

Ethinylestradiol

50

Norethisterone acetate

0 / 1

Sequostat

50

Levonorgestrel

0,05 / 0,125

Sequilar

50

Lynestrenol

0,05 / 2,5

Lyn-ratiopharm sequence

50

Chloromadinone acetate

1 / 2

Neo-Eunomine

50

Desogestrel

0 / 0,125

Oviol

Three-Phase Preparations

Ethinylestradiol

30/40/30

Levonorgestrel

0,05 / 0,075 / 0,125

Triquilar

30/50/40

Norethisterone

0,05 / 0,05 / 0,125

TriStep

35

Norethisterone

0,5 / 0,75 / 1

TriNovum


Side effects depending on the hormone potency

Symptom

Oestrogen

Gestagen

too much

shy of

too much

shy of

Acne

+

Candidavulvovaginitis

+

+

Chloasma

+

Depression

+

+

Breakthrough bleeding in the first cycle phase

+

Breakthrough bleeding in the second cycle phase

+

+

Dysmenorrhoea

+

Vomiting

+

Hair Loss

+

Hirsutism

+

Hypermenorrhoea

+

+

Hypertrichosis

+

hypo- and amenorrhoea

+

+

Headaches in the pill-free interval

+

Headaches while taking the tablets

+

slow weight gain, appetite increase

+

Libido reduction

+

+

Lubricatio deficiens

+

+

Mastodynia

+

+

Tiredness

+

Nervousness

+

rapid weight gain, water retention, oedema

+

Seborrhoea

+

Feeling of tension in the breasts

+

Nausea

+

Varices

+

Calf Cramps

+

cervical hypersecretion

+


Essential interactions of estrogen-progestin combinations

Antidiabetics, oral

Carbohydrate Tolerance ↓

Barbiturates

contraceptive effect ↓

Benzodiazepines

Benzodiazepine action ↑

Broadband antibiotics

contraceptive effect ↓

Carbamazepine

contraceptive effect ↓

Griseofulvin

Griseofulvin effect ↑

Phenytoin

contraceptive effect ↓

Rifampicin

contraceptive effect ↓

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Last updated on: 29.10.2020