Eosinophilic ulcer of the oral mucosaK12.1
Synonym(s)
DefinitionThis section has been translated automatically.
The eosinophilic ulcer of the oral mucosa is a rare, benign, painful, self-limited lesion (rarely a recurrent course) of unknown etiology, usually lasting several weeks (months).
EtiopathogenesisThis section has been translated automatically.
Unknown, traumatic (Sah K et al. 2017)?
ManifestationThis section has been translated automatically.
Any age; advanced adulthood is preferred; no sex predilection.
LocalizationThis section has been translated automatically.
Oral mucosa, preferably on the tongue
Clinical featuresThis section has been translated automatically.
Initially circumscribed nodular infiltrate, early ulceration. A solid, greasy, painful, 0.5-2.0 cm ulcer with prominent, firm margins persists (Lingaraju N et al. 2015).
HistologyThis section has been translated automatically.
Ulcer extending to the submucosa and the musculature with mixed-cell inflammatory infiltrate with prominent eosinophilia. No cell atypia observed. The determination of CD30+ cells is important for the differential diagnostic differentiation from the lymphomatoid papulose of the oral mucosa.
Differential diagnosisThis section has been translated automatically.
Squamous cell carcinoma, lymphoma of the oral mucosa; an etiopathogenetic relationship to the (rare) form of the oral lymphomatoid papulose is unclear (Schwartz Z et al. 2017).
Progression/forecastThis section has been translated automatically.
Characteristic is the limited course of 1-5 months, whereby the ulcer can heal spontaneously after probiotic biopsy.
Sugaya N et al. described a recurrent course over a period of 2.5 years.
Typical is the therapy resistance to the usual topical agents.
LiteratureThis section has been translated automatically.
- Didona D et al (2015) Eosinophilic ulcer of the tongue--Case report. An Bras Dermatol 90(3 Suppl 1):88-90.
- Lingaraju N et al. (2015) Eosinophilic ulcer of the tongue: a rare and confusing clinical entity. BMJ Case Rep pii: bcr2015210107
- Sah K et al (2017) Eosinophilic ulcer of the tongue masquerading as malignant ulcer: An unexplored distinct pathology. J Oral Maxillofac Pathol 21:321.
- Schwartz Z et al (2017) Oral lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma. Ann Diagn Pathol 31:50-55.
- Sugaya N et al (2018) Recurrent Oral Eosinophilic Ulcers of the Oral Mucosa. A Case Report. Open Dent J 12:19-23.