Endoglin
DefinitionThis section has been translated automatically.
Endoglin (CD105) is a homodimeric glycoprotein (180 kDa) found on endothelial cells and is essential for angiogenesis processes.
General informationThis section has been translated automatically.
Endoglin is preferentially found on endothelial cells of capillaries, veins and arteries. It acts as an accessory receptor for members of the TGF-ß family, which as growth factors have a decisive influence on the process of angiogenesis. Besides this importance, there is also evidence for an association with the formation of new blood vessels and the prognosis of neoplastic diseases. This finding has led to the development of antitumoral strategies by means of experimental applications of endoglin antibodies. The influence on ontogenesis was also postulated. Experiments with mice without the gene coding for endoglin have shown that they died due to cardiovascular abnormalities. In addition, the hypothesis was put forward that endogline plays a physiological role in the stroma-hematopoietic interaction during ontogenesis. In humans, it is known that an autosomal dominant mutation of the gene coding for endoglin plays an etiologic role in the development of type 1 teleangiectasia hereditaria haemorrhagica.
LiteratureThis section has been translated automatically.
- Barbara NP (1999) Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem 274: 584-594
- Takahashi N (2001) Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin. Clin Cancer Res 7: 524-532
- Sanz-Rodriguez F et al (2004) Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the lim family of proteins. J Biol Chem 279: 32858-32868
- Venkatesha S (2006) Solube endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12: 642-649