EmpactL51.0
Synonym(s)
Erythema multiforme associated with phenytoin and cranial radiation therapy
DefinitionThis section has been translated automatically.
Acronym for "erythema multiforme associated with phenytoin and cranial radiation therapy".
Clinical featuresThis section has been translated automatically.
Oncological patients with brain metastases are often administered phenytoin as a prophylactic measure to prevent seizures. In some patients, severe adverse events (see below drug reaction, adverse events) such as the development of erythema exsudativum multiforme (EEM) may occur. In a subgroup of these patients, who additionally undergo radiotherapy of their brain metastases, an exclusive occurrence of EEM-like lesions in the radiation field can be observed.
Case report(s)This section has been translated automatically.
- 52-year-old female patient who received whole-brain radiation because of a cerebral metastasized bronchial carcinoma and phenytoin as prophylaxis. 3 weeks after initiation of therapy with phenytoin, an erythema exsudativum multiforme with mucosal involvement, initially limited to the radiation area, was observed. After a few days it spread to the upper body.
- Therapy and course: Immediate discontinuation of Phenytoin, as well as the additional systemic administration of corticosteroids, high-dose immunoglobulins in combination with intensive local and pain therapy led to complete healing. Epicutaneous testing revealed a type IV sensitization to phenytoin.
LiteratureThis section has been translated automatically.
- Ahmed I et al (2004) Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of literature. Int J Dermatol 43: 67-73