Extensive viral exanthema similar to eczema herpeticatum caused by an infection with coxsackieviruses of types A16 (CV-A16) and A6 (CV-A6) in patients with atopic dermatitis.
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Eczema coxsackiumB34.1
DefinitionThis section has been translated automatically.
PathogenThis section has been translated automatically.
Hand-foot-and-mouth disease (HFMD) is caused by various serotypes of the enterovirus genus. Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) were previously thought to be the only pathogens responsible for this viral infection. However, this was corrected after Coxsackievirus A6 (CV-A6) was found to be the responsible species for an endemic outbreak of this disease in Finland in 2008. CV-A6 was also identified as the pathogen in a Turkish study (Ceylan AN et al. 2019).
Clinical featuresThis section has been translated automatically.
Patients initially present with a vesiculobullous, symmetrical exanthema. In the majority of patients, the exanthema affects > 10 % of the body surface. This is not only distributed in the classic areas of hand-foot-mouth disease such as palms, soles and buttocks, but also periorally, on the extremities and on the trunk. Other morphologies included Gianotti-Crosti-like (37%), petechial/purpuric (17%) changes and coarse lamellar desquamation on the palms of the hands and soles of the feet.
Complication(s)This section has been translated automatically.
Serious systemic complications are not to be expected.
LiteratureThis section has been translated automatically.
- Ceylan AN et al. (2019) Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6: A Preliminary Report from Istanbul. Pol J Microbiol 68:165-171.
- Ganguly S et al (2016) Eczema Coxsackium. Indian J Dermatol 61: 682-683.
- Lott JP et al. (2013) Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection. J Am Acad Dermatol 69:736-741
- Mathes EF et al. (2013) Eczema coxsackium and unusual cutaneous findings in an enterovirus outbreak. Pediatrics 132:e149-57
- Puenpa J et al. (2017) Development of single-step multiplex real-time RT-PCR assays for rapid diagnosis of enterovirus 71, coxsackievirus A6, and A16 in patients with hand, foot, and mouth disease. J Virol Methods 248: 92-99.
- Zhou H et al. (2012) Clinical characteristics of hand, foot and mouth disease in Harbin and the prediction of severe cases. Chin Med J (Engl) 125: 1261-1265