Dysmaturation epidermal

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Histological phenomenon that can occur in skin reactions induced by chemotherapeutic or biological agents (e.g. in the hand-foot syndrome). Pathogenetically it is a drug-induced maturation disorder of the epidermis. The histological picture is characterized by dyskeratoses, nuclear atypias and suprabasal mitoses (also atypical mitosis figures = star-burst-cells).

LiteratureThis section has been translated automatically.

  1. Kerl H et al (2016) Cutaneous drug reaction. In: Ceroni L et al (Hrsg) Histopathology of the skin. P. 196-197 Springer-Verlag GmbH Berlin-Heidelberg
  2. Llamas-Velasco M et al (2016) Regorafenib induced hand-foot skin reaction with striking epidermal dysmaturation- a new histopathological pattern associated with the use of multi-kinase inhibitors. Br J Dermatol doi: 10.1111/bjd.14417

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer