Didanosine
Synonym(s)
DDI; Dideoxyinosin
DefinitionThis section has been translated automatically.
Pharmacodynamics (Effect)This section has been translated automatically.
Nucleoside analogue, competitive inhibitor of the reverse transcriptase of HIV.
IndicationThis section has been translated automatically.
Combination therapy of HIV infection.
Limited indicationThis section has been translated automatically.
Restricted liver and kidney function, pregnancy, history of pancreatitis, simultaneous administration of medications that may cause pancreatitis (pentamidine i.v.) or peripheral neuropathies (e.g. isoniazid, vincristine).
Dosage and method of useThis section has been translated automatically.
Pat. > 60 kg KG: 1 time per day 400 mg p.o.; Pat. < 60 kg KG: 1 time per day 250 mg or 2 times per day 125 mg p.o. Note
! Intake on an empty stomach: No food should be taken 2 hours before and 2 hours after ingestion of tablets, and no food should be taken 30 minutes before and 30 minutes after ingestion of powder.
Undesirable effectsThis section has been translated automatically.
Pancreatitis, peripheral neuropathy, nausea, chills, fever, hyperhidrosis, headache, pruritus, allergic reactions, seizures, blood count disorders, abdominal pain.
Notice! Regular, initially weekly checks of amylase, BB, transaminases, bilirubin, alkaline phosphatase, uric acid. Immediate discontinuation of didanosine in case of clinical suspicion of pancreatitis or occurrence of peripheral neuropathy as well as asymptomatic hyperuricemia!
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
Hypersensitivity to didanosine, acute pancreatitis, lactation, simultaneous administration of rifampicin or rifabutin, phenylketonuria (tablets contain the sweetener aspartame).
PreparationsThis section has been translated automatically.
Videx hard capsules/powder
PatientinformationThis section has been translated automatically.
Take the tablets on an empty stomach or 2 hours before a meal. Chew tablets slowly or crush them manually. Do not swallow unchewed! Abstinence from alcohol. The patient must be informed about symptoms of pancreatitis!
TablesThis section has been translated automatically.
Essential interactions of didanosine (according to Brodt-Helm-Kamps: AIDS 2000)
Alcohol |
Pancreatitis risk ↑ |
Ciprofloxacin |
Ciprofloxacin plasma levels ↓ |
Ganciclovir i.v. |
Pancreatitis risk ↑, DDI plasma level ↑ by 65% |
Pentamidine i.v. |
Pancreatitis risk ↑ |