Dermatitis periorale granulomatous of childhoodL71.0
Synonym(s)
Childhood granulomatous periorificial dermatitis; Dermatitis; FACE; facial Afro-Caribbean childhood eruption (FACE); Gianotti-type perioral dermatitis; granulomatous; granulomatous perioral dermatitis; Perioral granulomatous dermatitis of childhood; periorifizielle; sarcoid-like granulomatous dermatitis
HistoryThis section has been translated automatically.
Gianotti, 1970
DefinitionThis section has been translated automatically.
Rare, self-limiting, granulomatous disease of the perioral, perinasal and ocular facial skin with occasional extrafacial involvement, occurring mainly in African-American and Caribbean children. S.a.o. rosacea, lupoid.
EtiopathogenesisThis section has been translated automatically.
Unknown. Hypothesis: Non-specific granulomatous response to various topical and systemic substances such as topical fluorinated corticosteroids, antiseptic solutions, formaldehyde, vaccines. Variant of perioral dermatitis?
ManifestationThis section has been translated automatically.
No sex preference.
Clinical featuresThis section has been translated automatically.
Grouped, monomorphic yellow-brown, asymptomatic, 0.1-0.3 cm large papules on partly reddened skin, rarely scaling, possibly diffuse effluvium. No general symptoms. Extracutaneous manifestations with blepharitis and conjunctivitis are possible.
HistologyThis section has been translated automatically.
Perifollicular non-cheesy granulomas or granulomatous infiltrates with epithelioid histiocytes in the dermis; partly focal erpidermal spongiosis.
DiagnosisThis section has been translated automatically.
Clinic, Histology
Differential diagnosisThis section has been translated automatically.
- Rosacea granulomatosa (inappropriate age)
- Sarcoidosis (no lung involvement)
- Mycoses (fungus detection)
- Mycobacterioses (pathogen detection)
- Blue syndrome (= familial juvenile systemic granulomatosis).
External therapyThis section has been translated automatically.
Metronidazole, erythromycin, ichthyol ointment (1-2%), therapy duration several weeks to months.
Cave! Contraindicated: Local and systemic corticosteroids.
Internal therapyThis section has been translated automatically.
Macrolides, e.g. erythromycin.
Progression/forecastThis section has been translated automatically.
Self-limiting; complete healing after a few months up to 3 years with the possibility of leaving flat atrophic scars. Accelerated healing under systemic and/or local antibiotic therapy.
LiteratureThis section has been translated automatically.
- Antony FC et al (2002) Childhood granulomatous periorificial dermatitis in an Asian girl--a variant of sarcoid? Clin Exp Dermatol 27: 275-276
- Frieden IJ et al (1989) Granulomatous perioral dermatitis in children. Arch Dermatol 125: 369-373
- Gianotti F et al (1970) Particuliere dermatite peri-orale infantile: oberservations sur cinq cas. Bull Soc Fr Dermatol Syph 77: 341
- Hafeez ZH (2003) Perioral dermatitis: an update. Int J Dermatol 42: 514-517
- Smitt JH et al (1991) Granulomatous perioral dermatitis (facial Afro-Caribbean childhood eruption [FACE]). Br J Dermatol 125: 399
- Urbatsch AJ et al (2002) Extrafacial and generalized granulomatous periorificial dermatitis. Arch Dermatol 138: 1354-1358
- Zalaudek I et al (2005) Childhood granulomatous periorificial dermatitis: a controversial disease. JDDG 3: 252-255