Consequences of a therapy with the synthetic pyrimidine nucleoside cytarabine. Cytarabine differs from the physiological nucleosides cytidine and deoxycytidine only in the sugar content: instead of ribose or deoxyribose, arabinose occurs in the cytarabine molecule. Cytarabine is a pyrimidine antagonist.
Cytarabine syndrome
DefinitionThis section has been translated automatically.
Clinical featuresThis section has been translated automatically.
The cytarabin syndrome manifests itself through fever, muscle and bone pain, and occasionally chest pain. Other symptoms: maculopapular exanthema, conjunctivitis and general feeling of illness. Cytarabine syndrome and usually occurs 6-12 hours after administration of the drug.
TherapyThis section has been translated automatically.
For treatment or prophylaxis, the administration of corticosteroids has proven to be helpful. If the symptoms are considered treatable, the combined use of corticosteroids should be considered with continued therapy.
LiteratureThis section has been translated automatically.
- Berg I et al (2013) Rash and ear swelling in a patient with febrile neutropenia. Int J Infect Dis 17:e360-e361.
- Cetkovská P et al (2002) High-dose cytosine arabinoside-induced cutaneous reactions.J Eur Acad Dermatol Venereol16:481-485.
- Ruben BS et al (2015) Generalized benign cutaneous reaction to cytarabine. J Am Acad Dermatol 73:821-828.