Cxcl13

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Acronym for "C-X-C motif chemokine 13". CXCL-13 is a 109 amino acid protein that acts as a chemoattractant (BLC) and a B cell-attracting chemokine 1 (BCA-1). CXCL13 belongs to the "Intercrine alpha family" also called "chemokine CXC". It acts chemotactically for B lymphocytes but not for T lymphocytes, monocytes and neutrophils and binds to BLR1/CXCR5. CXCL-13 labels follicular T cells. CXCL13 is considered a possible biomarker for systemic lupus erythematosus.

LiteratureThis section has been translated automatically.

  1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer Publishing House Berlin-Heidelberg p. 29.

  2. Houshmand P et al., (2003) Therapeutic applications in the chemokine superfamily.
    Curr Opin Chem Biol 7:457-460.

  3. Huber AK et al.(2015) Targeting CXCL13 During Neuroinflammation. Adv Neuroimmune Biol 6:1-8.

  4. Schiffer L et al(2015) CXCL13 as a new biomarker of systemic lupus erythematosus and lupus nephritis - from bench to bedside? Clin Exp Immunol 179:85-89.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer