Complement fixation reaction

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 07.02.2023

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Synonym(s)

KBR

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DefinitionThis section has been translated automatically.

Detection system of an antigen-antibody reaction under complement consumption.

IndicationThis section has been translated automatically.

Field of application: Diagnostics of viral infections, Wassermann complement binding reaction, Sabin-Feldman test.

ImplementationThis section has been translated automatically.

A known antigen and a well-dosed amount of complement is added to an unknown serum sample. An antigen-antibody reaction takes place in the serum, i.e. if antibodies against the known antigen are present, the complement is consumed. After the addition of an indicator system consisting of sheep erythrocytes and rabbit antibodies directed against them, if an antigen-antibody reaction has taken place and complement has thus been consumed, erythrocyte lysis does not occur.

Authors

Last updated on: 07.02.2023

Author: Prof. Dr. med. Peter Altmeyer