Synonym(s)
Chromosome mutation
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Change in the chromosome structure due to loss, exchange or duplication of segments, whereby both chromatids of a chromosome are affected. Chromosomal aberrations, with the exception of deficiencies (loss of chromosomal end pieces), are caused by illegitimate, i.e. crossing over at non-homologous sites (e.g. after radiation exposure, by chemical mutagens). Crossing over leads to deletion (loss of a middle piece), inversion (exchange of both ends) or formation of ring chromosomes.