Chlorambucil, cutaneous side effects

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

chlorambucil, side effects on the skin; Chlorambucil, skin side effects

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DefinitionThis section has been translated automatically.

Oral cytostatic drug from the group of nitrogen-lost derivatives (alkylant), which above all prevents the maturation and proliferation of lymphocytes. Chlorambucil and the closely related Melphalan have a similar mode of action to cyclophosphamide.

IndicationThis section has been translated automatically.

Chronic lymphatic leukemia, non-Hodgkin's lymphoma, Hodgkin's lymphoma, cutaneous T-cell lymphoma, lymphogranulomatosis. Also used for Waldenstrom's disease due to its good tolerability.

Isolated reports of positive effects are available for:

Dosage and method of useThis section has been translated automatically.

0,1-0,2 mg/kg bw/day p.o. as ED.

Undesirable effectsThis section has been translated automatically.

Cutane UAWs:

General: Amicrobial cystitis, fever, stomatitis, pharyngitis, conjunctivitis. Rare hemolytic anemia.

PreparationsThis section has been translated automatically.

Leukeran

LiteratureThis section has been translated automatically.

  1. Boras VV et al (2016) Drug induced oral ulcerations: case report. Acta Clin Croat 55:334-337.
  2. Clements P et al (1993) The course of skin involvement in systemic sclerosis over three years in a trial of chlorambucil versus placebo. Arthritis Rheum 36:1575-1579.
  3. Milligan A et al (1990) The use of chlorambucil in the treatment of bullous pemphigoid. J Am Acad Dermatol 22:796-801.
  4. Ozkan A et al (2007) Profuse erythema multiforme induced by chlorambucil. Ann Hematol 86:539-40.
  5. Quaglino P et al (2017) Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium Ann Oncol 28:2517-2525.
  6. Rosen AC et al (2014) Life-threatening dermatologic adverse events in oncology. Anticancer Drugs. 25:225-234.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer