Cefixim

Cefixim is an orally administered cephalosporin which, according to the recommendations of the Paul-Ehrlich-Society, belongs to the oral cephalosporins of group 3. Cephalosporins are bactericidal β-lactam antibiotics that inhibit the synthesis of the bacterial cell wall. They are easily accessible to the placenta and reach relevant concentrations in the amniotic fluid.

Respiratory and urinary tract infections caused by Gram-negative pathogens, gonorrhoea.

Experience during pregnancy

1st Trimenon: In several larger studies with evaluated pregnancies there was no evidence of an increased risk of malformation for cephalosporins Most experience is available for cefaclor, cefalexin and cefuroxime.

2 - 3 Trimenon / Perinatal: Previous observations speak against a fetotoxic risk.

Pregnancy recommendations: Planning of a therapy or planning of a pregnancy under therapy: Cefixim can be used during pregnancy if the germ spectrum requires it.

Better tested alternatives in pregnancy are penicillins, cefaclor, cefalexin, cefuroxime.

Lactation: Cefixim can be used during lactation if the germ spectrum requires it.

Note: As randomized studies are not allowed in pregnant women, knowledge about the safety of drugs is based on the evaluation of clinical experience.

• Adults/children > 12 years: 2 times 200 or 1 time 400 mg/day p.o.
• Children < 12 years: 8-12 mg/kg bw/day.

• Cefixim is an alternative therapy for the treatment of gonorrhoea. Dosage for gonorrhoea: single application of 400mg p.o. together with 1,5g azithromycin p.o.