Marker for: B cells; CD20 is not expressed on plasma cells; in low density also on T cells, Sternberg-Reed cells. CD20 is helpful in the diagnosis of diffuse large B-cell lymphomas, furthermore in ALL, B-cell CLL, hairy cell leukemia and Burkitt's lymphoma.
Structure: Membrane protein (isoforms 33, 35, 37 kDa)
Note: CD20 is involved in B cell development, activation and differentiation. Along with CD79a, it is considered the best B cell marker.
Application: FACS, IHC (P), IF
(see also below) Cluster of differentiation