Cd134

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 01.06.2022

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DefinitionThis section has been translated automatically.

CD134/TNFRSF4 (TNFRSF4 stands for "TNF Receptor Superfamily Member 4") is a member of the TNF receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with the adaptor proteins TRAF2 and TRAF5.

Immunohistochemical Data:

  • Marks activated CD4+ cells, virally stimulated CD4+ cells (high expression).
  • Structure: Transmembrane glycoprotein (35 kDa).
  • Application: FACS, IHC (G)

Note(s)This section has been translated automatically.

CD 134 belongs to the tumor necrosis factors. CD 134 is jointly responsible for the clonal expansion of CD4+ cells and for the formation of memory T cells. CD 134 also seems to be involved in T-cell adhesion processes.

LiteratureThis section has been translated automatically.

  1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.

Authors

Last updated on: 01.06.2022

Author: Prof. Dr. med. Peter Altmeyer