Cd128

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

CD181; CDw128a; CXCR1; IL-8RA

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DefinitionThis section has been translated automatically.

CD128 (CD stands for "cluster of differentiation") also CXCR1 (CXC-motif chemokine receptor 1) or interleukin-8-receptor alpha (IL-8RA) is a protein receptor that is expressed on the surface of neutrophilic granulocytes and macrophages.

Cytokines like interleukin 8 or CXCL6 (GCP-2) bind to the protein. This binding activates an intracellular signal transduction cascade, which leads to an increase in intracellular calcium concentration and in which G-proteins and MAP kinases are involved.

Interleukin-8 itself plays an important role in the initiation and maintenance of inflammatory and tumorous diseases (see Interleukin-8).

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer