Cd115
Synonym(s)
c-fms; M-CSFR
DefinitionThis section has been translated automatically.
The acronym CD stands for "Cluster of Differentiation" and refers to groups of cellular surface features that have been classified according to biochemical or functional criteria. The CD classification enables comprehensible transparency in immunohistological and immunological research and diagnostics.
CD115 is a monoclonal antibody that reacts with the mouse CD115 molecule, a receptor for a macophage colony-stimulating factor (M-CSF), also called colony-stimulating factor-1 (CSF-1). CD115 is expressed by monocytes, macrophages, osteoclasts, and some epithelial cells.
The CSF1 cytokine is encoded by the eponymous CSF-1 gene, which is located on chromosome 1p13.3. S.a.u. Cluster of differentiation
LiteratureThis section has been translated automatically.
- Lin W et al (2019) Function of CSF1 and IL34 in macrophage homeostasis, inflammation, and cancer. Front Immunol 10:2019. doi: 10.3389/fimmu.2019.02019
- Mo H et al. (2021) Overexpression of macrophage-colony stimulating factor-1 receptor as a prognostic factor for survival in cancer: A systematic review and meta-analysis. Medicine (Baltimore) 100:e25218.
- Wang Y et al. (2016) Nonredundant roles of keratinocyte-derived IL-34 and neutrophil-derived CSF1 in Langerhans cell renewal in the steady state and during inflammation. Eur J Immunol 46:552-559.