Carcinoma spinocellular desmoplasticC44.L; C80
Synonym(s)
Carcinoma desmoplastic; desmoplastic carcinoma; desmoplastic carcinoma of the skin; Desmoplastic squamous cell carcinoma
DefinitionThis section has been translated automatically.
Rare (about 8%) histological and clinical variant of squamous cell carcinoma of the skin with high metastatic potential and high local recurrence rate (about 25%) even with adequate surgical procedure.
Clinical featuresThis section has been translated automatically.
Clinically indistinguishable from other spinocellular carcinomas.
HistologyThis section has been translated automatically.
Fine strands or smaller tumor cell nests with atypical, very polymorphic keratinocytes surrounded by a broad desmoplastic stroma. The tumour tends to infiltrate growth along autochthonous structures such as nerves or vessels.
TherapyThis section has been translated automatically.
Generous surgical removal. Micrographic surgery is recommended as well as sentinel lymph node biopsy.
LiteratureThis section has been translated automatically.
- Breuninger H et al (1998) Desmoplastic squamous epithelial carcinoma of the skin and lower lip. A morphologic entity with great risk of metastasis and recurrence. dermatologist 49: 104-108
- Breuninger H et al (1997) Desmoplastic squamous cell carcinoma of skin and vermilion surface: a highly malignant subtype of skin cancer. Cancer 79: 915-919
- Norris CM Jr et al (1986) Desmoplastic squamous cell carcinoma of the tongue simulating myositis or fasciitis. Head neck surgery 9: 51-55
- Petter G, Haustein UF (2001) Rare and newly described histological variants of cutaneous squamous epithelial carcinoma. Classification by histopathology, cytomorphology and malignant potential. dermatologist 52: 288-297