Images (10)

Carcinoma cuniculatumC44.L5

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 09.05.2023

Dieser Artikel auf Deutsch

Synonym(s)

epithelioma cuniculatum; verrucous carcinoma

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

HistoryThis section has been translated automatically.

Ackerman, 1948; Aird, 1954

DefinitionThis section has been translated automatically.

Variant of the spinocellular carcinoma defined by the particular localization (inguinal skin), with a low degree of malignancy. S.a. Carcinoma verrucosum.

Occurrence/EpidemiologyThis section has been translated automatically.

Mostly in men. clustered in the 50th-70th LJ.

LocalizationThis section has been translated automatically.

On the feet, mostly in the area of the metatarsal head I, on the toes, medioplantar, on the heel. Also described on the perineum.

Clinical featuresThis section has been translated automatically.

On the sole of the foot, pressure-induced endophytic growth, in other places (e.g. toes) also exophytic, wart-like growth, rarely ulcerated, then painful yellowish or brownish-yellowish, firm nodule, which is traversed by deep fistulating crypts and filled with macerated keratinous masses. Fetor. No metastatic tendency!

HistologyThis section has been translated automatically.

Mature squamous cell carcinoma with a strong cornification tendency. Strikingly high degree of maturation, extensive absence of nuclear atypia, dyskeratotic cells and low number of mitoses.

Differential diagnosisThis section has been translated automatically.

Verrucae vulgares

malum perforans

amelanotic malignant melanoma

nevus verrucosus

TherapyThis section has been translated automatically.

According to the carcinoma verrucosum. Excision with micrographic preparation of the excidate, safe absence of tumor must be guaranteed. The danger of recurrence is high! No radiotherapy, as the tumour is not very sensitive to radiation (danger of radiation ulcer).

Progression/forecastThis section has been translated automatically.

Favourable, with adequate surgical procedure.

Note(s)This section has been translated automatically.

The term "carcinoma cuniculatum" is increasingly losing its meaning after florid oral papillomatosis together with florid oral papillomatosis, papillomatosis cutis carcinoides and condylomata gigantea were combined into the term "verrucous carcinoma of the skin/mucosa". In the literature, the terms are sometimes used synonymously, sometimes listed separately (histological distinction between carcinoma cuniculatum and verrucous carcinoma is possible). In dermatological literature, carcinoma cuniculatum (derived from cuniculus, meaning rabbit hole) is predominantly associated with infestation of the skin of the groin (sole of the foot/toe) on the basis of location.

LiteratureThis section has been translated automatically.

  1. Ackerman LV (1948) Verrucous carcinoma of oral cavity. Surgery 23: 670-678
  2. Aird J et al (1954) Epithelioma cuniculatum: a variety of squamos carcinoma peculiar to the foot. Br J Surg 42: 245-250
  3. Heinzerling LM et al (2003) treatment of verrucous carcinoma with imiquimod and CO2 laser ablation. Dermatology 207: 119-122
  4. Ho J et al (2000) An ulcerating verrucous plaque on the foot. Verrucous carcinoma (epithelioma cuniculatum). Arch Dermatol 136: 547-548, 550-551

  5. Cubic MJ et al (2012) Carcinoma cuniculatum: not a verrucous carcinoma. J Cutan catholic 39:1083-1087

  6. Mehta RK et al (2000) Treatment of verrucous carcinoma of vulva with acitretin. Br J Dermatol 142: 1195-1198
  7. Patel AN et al (2013) Pain-free treatment of carcinoma cuniculatum on the heel using Mohs micrographic surgery and ultrasonography-guided sciatic nerve block. Clin Exp Dermatol 38:569-571
  8. Already MP et al (2000) Presternal verrucous carcinoma.dermatologist 51: 766-769

  9. Tauber M et al (2014) Unresectable perineal cuniculatum carcinoma: partial remission using systemic isotretinoin and interferon-α2a therapy. Acta Derm Venereol 94:721-722

  10. Thomas EJ et al (2014) Carcinoma cuniculatum: an atypical presentation in the foot. J Foot Ankle Surgery 53:356-359

Authors

Last updated on: 09.05.2023

Author: Prof. Dr. med. Peter Altmeyer