Bullhead-1

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

DKK-1

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DefinitionThis section has been translated automatically.

Extracellular protein that acts as an inhibitor in the WNT signalling pathway. This signalling pathway consists of different This signaling pathway consists of various glycoproteins that activate cell membrane-mediated signal transductions, including the proliferation and activity of melanocytes. DKK-1 also prevents the uptake of melanin into the keratinocytes. The WNT/beta-catenin signalling cascade (see below catenins) is involved in various cell activities, such as lifespan, proliferation, cell migration, polarity and gene expression. DKK-1 plays a key role in the control of developmental processes. DKK-1 also plays a role in the regulation of bone metabolism. It inhibits the differentiation of osteoblasts. DKK-1 is also produced by various tumour cells (colon carcinoma, multiple myeloma).

LiteratureThis section has been translated automatically.

  1. Brenner M et al (2010) Basics of skin pigmentation. Dermatologist 61: 554-560
  2. Giehl K et al (2010) Genetically caused pigmentation disorders. Dermatologist 61: 567-577

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer