Artemether/lumefantrine
DefinitionThis section has been translated automatically.
Spectrum of actionThis section has been translated automatically.
Effective against sexually mature forms (gametocytes) of Pl. falciparum (also for chloroquine resistance).
IndicationThis section has been translated automatically.
Acute, uncomplicated malaria tropica (Pl. falciparum) in patients > 12 years and > 35 kg bw.
Notice! Not suitable for malaria prophylaxis!
Dosage and method of useThis section has been translated automatically.
Adults/children > 12 years and > 35 kg bw: 6 times 4 tablets (20 mg artemether/120 mg lumefantrine per tablet) over a total of 60 hours (ED with 4 Tbl. each at the start of therapy, after 8, 24, 36, 48 and 60 hours). To be taken with a high-fat meal!
Notice! In case of vomiting of the medication within 1-3 hours after application, repeat the intake!
Undesirable effectsThis section has been translated automatically.
Headache, dizziness, abdominal pain, loss of appetite, nausea, myalgia, pruritus, skin changes.
ContraindicationThis section has been translated automatically.
Complicated malaria tropica, cardiac arrhythmias, comedication with CYP2D6 substrates (e.g. amitriptyline, metoprolol) or CYP3A4 inhibitors (e.g. erythromycin, ketoconazole, itraconazole)
PreparationsThis section has been translated automatically.
Riamet
Note(s)This section has been translated automatically.
Remember! For patients with severe kidney or liver dysfunction: ECG and laboratory tests!