AriboflavinosisE53.00
Synonym(s)
oroculo-genital syndrome; pellagra sine pellagra; Riboflavin deficiency; Vitamin B2 deficiency; vulvitis pellagrosa
DefinitionThis section has been translated automatically.
In cases of long-term (several years) undersupply of vitamin B2, eczematous, macerative skin changes, especially in the body orifices, microcytic hypochromic anaemia and scaly rhagadiform erythema (genital, seborrhoeic predilection sites of the face) as well as paronychia occur.
EtiopathogenesisThis section has been translated automatically.
A variety of causes have been described, e.g. triggering by drugs such as tricyclic antidepressants (inhibition of flavokinase) or underlying diseases, which are frequently triggered by vitamin B2 deficiency.
Pathogenetically decisive is often the reduced vitamin B2 intake due to insufficient and unbalanced nutrition as well as due to absorption disorders in diseases of the gastrointestinal tract ( celiac disease, chronic enteritis) and changes in the physiological intestinal flora (e.g. antibiotic therapy).
LocalizationThis section has been translated automatically.
Lips, corner of the mouth, nostrils and nasolabial folds, eyelids, external auditory canal, genitals (oro-oculo-genital syndrome).
Clinical featuresThis section has been translated automatically.
- Integument: Eczematous, wet-crusted skin changes, rhagades. The lips are smooth, bright red and chapped, with weeping fissures covered with bark, cheilosis, perlèche, stomatitis, glossitis. The chronic eczematous changes of the genital region are called pellagroid scrotal dermatitis or vulvitis pellagrosa.
- Eye: Photophobia, fatigue, reduced visual acuity, vascularization of the cornea and pericorneal area, spots and opacities on the cornea.
- In the infant: growth and weight stagnation, desiccation.
DiagnosisThis section has been translated automatically.
Determination of the vitamin B2 blood level.
External therapyThis section has been translated automatically.
Symptomatic therapy with nourishing, greasing external agents (e.g. Ungt. emulsif. aq., Ash Base Cream, Linola Cream, Excipial U Lipolotio). Exteriors that oil the lips (e.g. Bepanthen Lip Cream, Ceralip Lip Cream).
Internal therapyThis section has been translated automatically.
Substitution therapy e.g. with Multibionta forte N soft capsules 1 time a day 1 tbl (1 soft capsule contains 12.5 mg riboflavin).
LiteratureThis section has been translated automatically.
- Yates CA et al (2003) Absence of luminal riboflavin disturbs early postnatal development of the gastrointestinal tract. Dig Dis Sci 48: 1159-1164