Antihistamines, h2-antagonists

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 13.09.2021

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Synonym(s)

H2 antagonists; H2-receptor blockers

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DefinitionThis section has been translated automatically.

Drugs that block H2-receptors of the document cells in the stomach and lead to the healing of ventricular and duodenal ulcers by reducing acid secretion.

IndicationThis section has been translated automatically.

H2-antagonists are used in dermatology as concomitant medication in systemic glucocorticoid, immunosuppressive or cytostatic therapy.

Limited indicationThis section has been translated automatically.

Pregnancy, nursing, renal failure.

Dosage and method of useThis section has been translated automatically.

S. Tab.

Undesirable effectsThis section has been translated automatically.

Allergic reactions, CNS disorders, dizziness, blood formation disorders, eosinophilia, bronchospasms, gastrointestinal disorders.

InteractionsThis section has been translated automatically.

S. Tab.

ContraindicationThis section has been translated automatically.

Paragroup allergy (applies only to suspensions), sorbitol intolerance (applies only to suspensions), children and adolescents < 16 years, porphyria, severe hepatic dysfunction, anuria .

TablesThis section has been translated automatically.

Major interactions of H2 antagonists

Acenocoumarol

Bleeding tendency ↑

Barbiturates

Barbiturate levels ↑

Captopril

Neuropathy ↑

Carbamazepine

Carbamazepine levels ↑

Carmustine

Carmustine toxicity ↑, myelosuppression ↑

Chlordiazepoxide

Chlordiazepoxide levels ↑

Chlorpromazine

Fatigue ↑

Clomethiazole

Clomethiazole levels ↑

Digitoxin

Digitoxin toxicity ↑

Diltiazem

Diltiazem toxicity ↑

Iron

Iron level ↓

Erythromycin

Erythromycin toxicity ↑, hearing impairment ↑.

Halofrantine

Halofrantine bioavailability ↓, avoid combination.

Hydromorphone

Hydromorphone levels ↑

Isradipine

Isradipine levels ↑, RR drop, halve dose of isradipine

Itraconazole

Itraconazole levels ↓, take 2 hrs apart.

Ketoconazole

Ketoconazole level ↓

Labetalol

Labetalol level ↑

Levomethadone

Levomethadone level ↑

Lidocaine i.v.

Lidocaine level ↑, halve lidocaine dose.

Magnesium antacids

H2 antagonist levels ↓, take 2 hrs apart.

Mebendazole

Mebendazole levels ↑

Metformin

Metformin levels↑, lactic acidosis

Metoclopramide

H2 antagonist levels ↓, take 2 hrs apart.

Metoprolol

Metoprolol levels ↑, bradycardia

Nifedipine

Nifedipine level ↑, RR drop.

Nicotine abuse

H2 antagonist effect ↓

Opioid analgesics

Opioid toxicity ↑, seizures, confusional states, respiratory failure

Phenytoin

Phenytoin levels ↑.

Procainamide

Procainamide levels ↑, conduction disorders

Propanolol

Propanolol levels ↑, bradycardia

Rifabutin

Rifabutin levels ↑.

Sulfonylurea antidiabetics

Antidiabetic effect ↑

Terbinafine

Terbinafine levels ↑

Tetracyclines

Tetracycline effect ↓

Theophylline

Theophylline levels ↑

Valproic acid

Valproic acid level ↑

Warfarin

Bleeding tendency ↑

Zidovudine

Zidovudine toxicity ↑

Overview of the main H2 antagonists and their dosage.

Active ingredient

Dosage

Preparation

Cimetidine

400 mg/day p.o.

Tagamet

Famotidine

20 mg/day p.o. in the evening

Pepdul

Nizatadine

200 mg/day p.o. in the evening

Nizax

Ranitidine

300 mg/day p.o. in the evening

Sostril, Zantic

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Last updated on: 13.09.2021