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antibodies with amino acid sequences from different species, e.g. mixed human/mouse antibodies. In mixed human/mouse antibodies, the variable regions that determine their specificity consist of a mouse monoclonal antibody. The constant part of the immunoglobulin molecule comes from a human source. Chimeric antibodies are very similar to human antibodies and are not, or are less rapidly, rejected, as is the case with pure mouse antibodies when they are repeatedly injected into humans.