Angiolymphoid hyperplasia with eosinophiliaL98.9

Multicentric, benign lymphoproliferative hyperplasia, clinically characterized by dermal nodules and nodules, but also by subcutaneously located nodules with edema, lymphocytic and eosinophilic infiltrates, formation of germinal centers, fibrosis, and hyperplasia of blood vessels. Most authors separate Kimura's disease from angiolymphoid hyperplasia with eosinophilia on the basis of clinical and histological criteria. Obviously, overlaps of both syndromes are observed. However, the separate entity appears to be secure.

Panethnic among men and women of all ages. Unlike M. Kimura, no preference for the Asian population.

Head, especially ear region, orbita, forehead and capillitium, neck; more rarely extremities and genital area, vulva or penis.

In Kimura's disease, the scalp and neck region are preferentially affected.

Solitary, rarely grouped in plural, asymptomatic or painful, also pruritic, red or brown-red, brown, firm, about 0.5-0.8cm in size, papules and nodules with a smooth surface. Also appearing as deep nodules.

Solitary or multiple, 2-40 mm, hemispherical, red, to reddish-brown, rarely purplish or ulcerated nodules and nodules. Rarely disseminated appearance or lymphadenopathy. Usually asymptomatic or painful, also pruritic (pruritus is absent in Kimura's disease!). In Kimura's disease, larger subcutaneous (also intramuscular) non-pruritic nodules are observed.

Atheroma; epidermal cysts; cylindroma; hemangioma; granuloma teleangiectaticum; angiosarcoma; Kaposi's sarcoma; granuloma eosinophilicum faciei; lymphadenosis cutis benigna.

These are individual case reports. Larger experiences are not available due to the rarity of the disease.

Excision in case of longer duration. Risk of recurrence! Risk of bleeding!

CO2 laser may also be used.

Recurrence treatment in patients > 65 years, if necessary with X-rays (GD: 20-30 Gy). Combinations of CO2 laser irradiation with intralesional glucocorticoid application such as triamcinolone acetonide crystal suspension (e.g. Volon A diluted 1:3 with a local anaesthetic, e.g. Scandicaine) have also been described as successful.

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