Albendazole
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
1,5 h
Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of the polymerisation of the tubulin structures of the cytoskeleton with the consequence of degenerative changes in the intestine and segment of the worms.
Spectrum of actionThis section has been translated automatically.
Ancylostoma duodenale, Ascaris lumbricoides, Enterobius vermicularis, Necator americanus, Trichuris trichiura, Echinococcus spp.
IndicationThis section has been translated automatically.
- Infections with helminths in trichinosis, strongyloidosis, larva migrans, filariasis (loiasis).
- Inoperable or not radically operable forms of infections with Echinococcus cysticus (dog tapeworm) and Echinococcus alveolaris (fox tapeworm) for preoperative support of surgical therapy.
Limited indicationThis section has been translated automatically.
Children < 6 years.
Dosage and method of useThis section has been translated automatically.
See Table 1.
Note! In women of childbearing age: Effective anticonceptive treatment (ovulation inhibitors are not sufficient!) before, during and one month after therapy!
Undesirable effectsThis section has been translated automatically.
During the first days of treatment: fever and/or nosebleed, pruritus, exanthema, hair loss, dizziness, headache, gastrointestinal problems, transaminase increases, leucopenia, pancytopenia, aspermia.
Notice! Check liver values and BB before each treatment, after 5 and 10 days, then every 14 days. Stop treatment if the values increase more than twice the norm!
ContraindicationThis section has been translated automatically.
Pregnancy, lactation, children < 3 years.
PreparationsThis section has been translated automatically.
Eskazole
PatientinformationThis section has been translated automatically.
Taking tablets with a fatty diet!
TablesThis section has been translated automatically.
Dosage of Albendazole
Indication |
Dosage |
Ancylostoma brazilse |
400 mg/day p.o. over 2 days |
duodenal ancylostoma |
400 mg/day p.o. as ED |
angiostrongylus cantonensis |
100 mg/12 hours p.o. over 8 days |
Ascaris lumbricoides |
400 mg/day p.o. as ED |
Echinococcus cysticus |
5 mg/kg bw/12 hrs over 4 weeks, repeat therapy cycle after 14-day break, not more than 3 therapy cycles in total |
Echinococcus alveolaris and multilocularis |
see above, but intermittent long-term therapy over months to years |
larva currens |
400 mg/day p.o. over 3 days |
larva migrans |
400 mg/day p.o. over 3 days |
Necator americanus |
400 mg/day p.o. as ED |
trichuris trichiura |
400 mg/day p.o. over 3 days |
Strongyloides stercoralis |
20 mg/day in 3 doses over 3 days |