Smaller protein group (5 members have been described so far) with a large homology to the ADAMTS family of a group of zinc-containing metalloproteinases, which has 20 members so far.
The ADAMTS-like protein 5 was identified as an autoantigen produced by melanocytes. It is presented in psoriatic inflammation by the HLA major risk gene HLA-C*06:02 and can then be recognized by the T-cell receptor (TCR) Vα3S1/Vβ13S1 on Th17 cells.