The term "acute syndrome of apoptotic pan-epidermolysis" (ASAP) denotes a severe clinical clinical picture with features of erythema multiforme (up to its maximum variant, Stevens-Johnson syndrome) and (bullous) systemic lupus erythematosus. Histologically striking is a prominent apoptotic cleavage of the epidermis due to acute damage of the epidermal basal cells. Triggering factors are frequently drugs, if necessary in combination with UV exposure.
Although no symptom is conclusive on its own, a combination of recent (S)LE exacerbation, obvious photodistribution, anular lesions, absent or only mild focal erosive mucosal involvement may support the diagnosis of LE.