ATP-binding cassette transporters (ABCs) are specialized proteins that actively release physiological compounds and xenobiotics from cells. They are involved in physiological processes with bile acids, conjugated steroids and cyclic nucleotides. The ABCC11 protein stimulates ATP-dependent uptake of a number of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, Steroid sulfates such as dehydroepiandrosterone-3-sulfate (DHEAS) and estrone-3-sulfate, glucuronides such as estradiol-17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. The ABCC11 protein also increases cellular release of cAMP and cGMP. It confers resistance to anticancer drugs such as 5-fluorouracil (5-FU) and methotrexate.
ABCC11 Gene
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- Kruh GDet al (2007) ABCC10, ABCC11, and ABCC12. Pflugers Arch 453:675-684.
- Toyoda Yet al. (2016) Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence. Biomed Res Int: 7670483.