Abacavir
DefinitionThis section has been translated automatically.
Virustatic. Nucleoside inhibitor of HIV reverse transcriptase.
IndicationThis section has been translated automatically.
Antiretroviral combination therapy for the treatment of HIV-1 infection in patients > 3 months
Pregnancy/nursing periodThis section has been translated automatically.
Contraindicated.
Dosage and method of useThis section has been translated automatically.
- Adults and children > 12 years: 2 times/day 300 mg p.o.
- Children 3 months - 12 years: 2 times/day 8 mg/kg bw p.o. Maximum daily dose: 600 mg.
Undesirable effectsThis section has been translated automatically.
Headaches, dizziness, fatigue, gastrointestinal symptoms such as nausea, vomiting. Cutaneous NW (10-15% of patients, usually occurring within the first 6 weeks of treatment) such as erythema, erythema exsudativum multiforme, urticaria, maculopapular exanthema.
Cave! In case of hypersensitivity syndrome (approx. 5% of patients) with skin changes, fever and flu-like symptoms, the therapy must be discontinued and a new intake must be avoided for life!
ContraindicationThis section has been translated automatically.
Pat. with severe liver and kidney dysfunction (e.g. WHO group III-IV). Hypersensitivity reactions to abacavir or other ingredients of the drug.
PreparationsThis section has been translated automatically.
Ziagen